Atherosclerosis
Conditions
Keywords
Atherosclerosis, Subjects diagnosed with atherosclerosis
Brief summary
The purpose of this study is to utilize high-resolution CMR carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis. Patients who are scheduled to undergo an imaging procedure will be recruited from the cath lab. Upon enrollment, blood samples conventional and genetic profiling will be collected. For patients undergoing a carotid endarterectomy, tissue from the carotid vessel will be collected during their procedure. Comparison of the MR images with tissue and/or blood samples will be made. Length of time in the study will be approximately 1 day. There will be no study-related patient follow-up.
Interventions
None listed
Sponsors
Piedmont Healthcare
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age range \>17 years of age * Surgical carotid artery disease * Provide written informed consent and Authorization for Use/Disclosure of PHI
Exclusion criteria
* History of carotid trauma * History of middle or large vessel vasculitis * Refusal to provide written informed consent and Authorization for * Use/Disclosure of PHI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization of plaque that is found in the carotid walls of patients who have atherosclerosis | 2 years post study initiation |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effectiveness of MR imaging in identifying these plaque characteristics | 2 Years Post Study Initiation |
Countries
United States
Outcome results
None listed