Hyperemesis Gravidarum
Conditions
Keywords
nausea, vomiting, pregnancy, thiamine, promethazine, nausea and vomiting in pregnancy
Brief summary
There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.
Detailed description
* Research groups: pregnant women eho visit the emergency room for nausea and vomiting in pregnancy, pregnancy age 12 weeks or less * After basic examinations and hydration, the women will randomized to thiamine or promethazine treatment. * If no improvement is shown, the patient will be treated with the other drug * The patients will be interviewed on their current visit and every two weeks until 14th week of gestation * The interview includes medical history and details about their illness, other treatments, hospitalization etc.
Interventions
DRUGthiamine & promethazine
thiamine 100 mg IV promethazine 25 mg IV
Sponsors
HaEmek Medical Center, Israel
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Pregnant women until 12th week of gestation * The women visit the ER because of nausea and vomiting * The women didn't received thiamine yet
Exclusion criteria
* Pregnant women over 12th week of gestation * Women that received thiamine before * women that allergic to the studied drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the improvement in nausea and/or vomiting after treatment | 2 months after first visit in ER (until 14 week of pregnancy) |
Countries
Israel
Outcome results
None listed