Goal Directed Fluid Therapy
Conditions
Keywords
goal directed fluid therapy, lean patients, obese patients, crystalloids, Esophageal Doppler, tissue oxygenation, Fluid management during surgery, Fluid management
Brief summary
Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.
Detailed description
To our knowledge no data are available on the effect of goal-directed fluid therapy on hemodynamics in lean patients and obese patients, respectively. Consequently, we want to compare lean patients (BMI \<25) vs. obese patients (BMI \>25) in regard of their respective needs for intraoperative fluid therapy, and the impact of the goal-directed fluid regimen on tissue oxygenation.
Interventions
DRUGfluidotherapy with ringer-lactate
a bolus of 250ml ringer-lactate is administered, if there is fluid demand monitored by the Esophageal Doppler
Sponsors
Medical University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* female patients (18 - 80 years) undergoing elective gynecological open surgery (hysterectomy, ovarian cysts and tumors, myomectomy, endometriosis)
Exclusion criteria
* cardiac insufficiency (EF\< 35%) * renal insufficiency (creatinin clearance \<30ml/min, dialysis) * insulin dependant diabetes mellitus * coagulopathy * NYHA IV * infection * sepsis * history of suspect malignant hyperthermia * porphyria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| different hemodynamic fluid responses in the different groups | every 10 minutes during surgery |
Secondary
| Measure | Time frame |
|---|---|
| Subcutaneous oxygen tension (PsqO2) | every 10 minutes during surgery and 2 hours postoperatively |
Countries
Austria
Outcome results
None listed