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Giardia Induced Fatigue and Functional Gastrointestinal Diseases

Chronic Fatigue Syndrome and Abdominal Symptoms After Giardia Infection: Clinical Evaluation, Biomarkers, Risk Factors and the Effect of Intervention

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00860236
Acronym
GIFF
Enrollment
40
Registered
2009-03-12
Start date
2009-03-31
Completion date
2010-06-30
Last updated
2017-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Fatigue Syndrome

Keywords

CFS, Giardia, Fatigue, Cognitive behavioural therapy, CBT, Chronic fatigue syndrome

Brief summary

A giardiasis outbreak in Bergen has given us the opportunity to approach two basic research questions of national and global importance: * Studying the pathoimmunology of giardiasis in a natural setting, and following the genetic and immunological responses leading to recovery or persistent disease and sequelae. * Studying the two disease entities FGID and CFS when induced by acute giardiasi and their risk factors. * Interventional cognitive behavioural therapy is the only intervention documented to have significant effect on CFS outcome, and conventional cognitive behavioural therapy will be compared to a psycho-educational programme in the format of a randomised controlled trial.

Interventions

OTHERPsycoeducation/counseling

2 days of education on mechanisms of illness and coping strategies

BEHAVIORALCognitive behavioural therapy

4 days intensive training in understanding and behavioural changes

Sponsors

University of Bergen
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Problems with fatigue of any severity after Giardia infection

Design outcomes

Primary

MeasureTime frame
Improvement minimum 6 points in Chalder Fatigue scale score6 months

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026