Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00858585

Enrollment

149

Registered

2009-03-10

Start date

2009-03-31

Completion date

2016-09-30

Last updated

2019-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Keywords

Bone metastasis, SNP concordance

Brief summary

This study will examine genes in three different tissues and look for similarities and differences between normal cells and cancer cells. The tissues to be studies come from blood, lymph node and cancer.

Detailed description

Subjects will be given an informed consent to read and sign The medical chart will be reviewed for diagnosis and treatment history Blood (about 4 tablespoons) will be drawn at a clinically available time. The lymph node and breast tumor tissue in the University of Michigan pathology repository will be used for research purposes

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age at least 18 years of age * Able to read and sign the informed consent * Able to provide specimens: one blood draw for white blood cells, provide permission to use tissue already collected.

Design outcomes

Primary

Measure	Time frame	Description
Single nucleotide polymorphisms	time-independent	Determine single nucleotide polymorphism concordances between the three DNA specimen sources

Countries

United States

Outcome results