Hepatocellular Carcinoma
Conditions
Keywords
markers, expression analysis
Brief summary
Hepatocellular carcinoma is an aggressive disease with limited therapeutic options. Therefore, new approaches to treat this type of cancer are needed with immunotherapy potentially being one of these. As a first step in the development of novel therapies, expression analysis of specific markers, including tumor antigens will be carried out. This will be done retrospectively using available hepatocellular carcinoma tissue samples.
Interventions
RNA extracted from tissue samples already archived
Sponsors
GlaxoSmithKline
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* The patient had pathologically proven hepatocellular carcinoma * All the data required are available from patient's records * A sufficient amount of RNA is available for all three tissue samples
Exclusion criteria
N/A
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will also analyze whether this gene-expression signature is present in matched cirrhotic tissue and the interface tissue with the tumor. | At the time of analysis. |
| Proportion of hepatocellular carcinoma cancer patients whose tumor tissue -expresses any one or more of specific target antigens -overexpresses c-MET -expresses a pre-defied gene-expression signature | At the time of analysis. |
Countries
Italy
Outcome results
None listed