Obesity
Conditions
Keywords
obesity, arthritis
Brief summary
Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.
Detailed description
The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.
Interventions
None listed
Sponsors
US Department of Veterans Affairs
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Adults aged 20-60 who have no history of LE surgery * Healthy adults able to walk 30 minutes * Healthy adults able to have MR
Exclusion criteria
* Adults who have had LE surgery * Adults cannot walk 30 minutes * Adults who cannot tolerate MR * Adults with osteoarthritis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gait Knee Adduction Moment | baseline or first and only visit. | — |
| Cartilage Thickness | baseline or first and only visit. | Medial/lateral thickness ratio |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Normal Weight Body mass index between 18 and 25 kg/m\^2, no self-reported chronic pain or significant injury in any of the lower extremity joints or lower back | 70 |
| Overweight Body mass index between 25 and 30 kg/m\^2, no self-reported chronic pain or significant injury in any of the lower extremity joints or lower back | 52 |
| Obese Body mass index between 30 and 50 kg/m\^2, no self-reported chronic pain or significant injury in any of the lower extremity joints or lower back | 55 |
| Total | 177 |
Baseline characteristics
| Characteristic | Normal Weight | Overweight | Obese | Total |
|---|---|---|---|---|
| Age, Continuous | 39.2 years STANDARD_DEVIATION 11.99 | 40.91 years STANDARD_DEVIATION 13.08 | 39.8 years STANDARD_DEVIATION 11.27 | 39.89 years STANDARD_DEVIATION 12.06 |
| Sex: Female, Male Female | 40 Participants | 16 Participants | 34 Participants | 90 Participants |
| Sex: Female, Male Male | 30 Participants | 36 Participants | 21 Participants | 87 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk |
|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — |
| other Total, other adverse events | 0 / 0 | 0 / 0 | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 | 0 / 0 | 0 / 0 |
Outcome results
Primary
Cartilage Thickness
Medial/lateral thickness ratio
Time frame: baseline or first and only visit.
Population: Overweight and obese were combined based on similarities found in literature. Subjects were excluded based on MRI evidence of cartilage defects, osteophytes, ligament tears, meniscal tears, or bone marrow edema.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Normal Weight | Cartilage Thickness | 1.069 mm/mm | Standard Deviation 0.097 |
| Obese | Cartilage Thickness | 1.04571 mm/mm | Standard Deviation 0.169 |
| Normal Weight Middle Age | Cartilage Thickness | 1.051 mm/mm | Standard Deviation 0.127 |
| Overweight and Obese Middle Age | Cartilage Thickness | 1.069 mm/mm | Standard Deviation 0.139 |
Primary
Gait Knee Adduction Moment
Time frame: baseline or first and only visit.
Population: Obese were compared to healthy weight subjects. No overweight subjects were used in this analysis. Subjects were excluded based on MRI evidence of cartilage defects, osteophytes, ligament tears, meniscal tears, or bone marrow edema.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Normal Weight | Gait Knee Adduction Moment | 3.14 percent body weight (N)*height (m) | Standard Deviation 0.816 |
| Obese | Gait Knee Adduction Moment | 2.39 percent body weight (N)*height (m) | Standard Deviation 0.765 |