Cardiac Surgery
Conditions
Brief summary
Several studies have highlighted the cardioprotective effects of acute normovolemic hemodilution during cardiac surgery. The aim of our study is to show that an increase in endogenous erythropoietin (EPO) might explain the cardioprotective effects of acute normovolemic hemodilution against ischemia-reperfusion phenomena.
Detailed description
The major physiologic function of EPO is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO has tissue-protective effects and prevents tissue damage during ischemia. In an ex vivo proof-of-concept, protective effects of EPO have been shown in human myocardium. Several studies have demonstrated that acute normovolemic hemodilution before aortic cross clamping decreases perioperative myocardial damage. We hypothesized that the onset of acute anemia increases the endogenous EPO concentration, which explains the cardioprotective effects of acute normovolemic hemodilution.
Interventions
PROCEDUREacute normovolemic hemodilution
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients between 18 and 80 years old undergoing CABG with or without cardiopulmonary bypass
Exclusion criteria
* emergencies * redo operations * combined surgery * men with Hb\< 120g/dL and women with Hb\< 110g/ dL * patients with preoperative creatinine\> 2.2 mg/dL * poor ventricular function (EF \< 50%) * subjects with a pulmonary disease, hepatic disease * subjects with carotid stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in Troponin -I values | 4 h |
Countries
Belgium
Outcome results
None listed