Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00854178

Enrollment

Registered

2009-03-03

Start date

2008-03-31

Completion date

2009-12-31

Last updated

2010-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DNA Damage, Patients in Good Health, Types of General Anesthesia

Keywords

isoflurane, propofol, genotoxicity, gene expression, cytokines, apoptosis

Brief summary

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

Detailed description

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.

Interventions

DRUGComparison of two anesthetic drugs

Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* patients in good health American Society of Anesthesia status physical I * elective minor surgery * general anesthesia

Exclusion criteria

* smokers * alcoholics * previous medication or radiation

Design outcomes

Primary

Measure	Time frame
Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile	within 1 day after surgery

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026