Acute Pancreatitis
Conditions
Brief summary
Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.
Detailed description
Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis. Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.
Interventions
OTHERGoal-directed fluid resuscitation
Targeted, weight-based fluid resuscitation
Sponsors
Dartmouth-Hitchcock Medical Center
Brigham and Women's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute pancreatitis diagnosed by at least 2 criteria * adult patients at least 18 years of age
Exclusion criteria
* history of severe cardiovascular, respiratory, renal, hepatic or hematologic/immunologic disease * concurrent metabolic or physiologic derangement requiring specific fluid management * pregnancy * patients transferred from acute care hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence (point prevalence) of the systemic inflammatory response syndrome (SIRS) at 24 hours | first 24 hours of hospitalization |
Countries
United States
Outcome results
None listed