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A Cluster Randomized Trial to Evaluate Long Lasting Insecticidal Hammocks to Prevent Forest Malaria in Vietnam

A Cluster Randomized Trial to Evaluate the Effectiveness of Long Lasting Insecticidal Hammocks for Controlling Forest Malaria in Central Vietnam

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00853281
Enrollment
18646
Registered
2009-03-02
Start date
2004-03-31
Completion date
2007-06-30
Last updated
2010-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Keywords

Forest malaria prevention, Long-lasting insecticidal hammocks, Cluster randomized trial, Central Vietnam

Brief summary

In Central Vietnam, forest malaria remains difficult to control due to the complex interactions between human, vector and environmental factors. Untreated bednets had a significantly protecting effect for villagers, except for those regularly sleeping in the forest, who suffer a significantly higher number of clinical attacks. Thus, there is need to target this high-risk group with new intervention based on long-lasting insecticidal materials. Hammocks are extensively used by people working in the forest, therefore long-lasting insecticidal hammocks (LLIH) could achieve a good individual protection. The Investigators proposed to evaluate their effectiveness in a community-based trial, comparing them to the standard vector control methods (insecticide-treated nets).

Detailed description

In Central Vietnam, forest malaria remains difficult to control due to the complex interactions between human, vector and environmental factors. A community-based study carried out between 1999 and 2001 showed that regular forest activity was a strong risk factor for malaria infection. Untreated bednets had a significantly protecting effect for villagers, except for those regularly sleeping in the forest, who suffered a significantly higher number of clinical attacks. Thus, there is need to target this high-risk group with new intervention based on long-lasting insecticidal materials. Hammocks are extensively used by people working in the forest, therefore long-lasting insecticidal hammocks (LLIH) could achieve a good individual protection. The Investigators proposed to evaluate their effectiveness in a community-based trial, comparing them to the standard vector control methods (insecticide-treated nets): communities have been grouped into clusters of about 1000 înhabitants, and clusters were randomized to either the active intervention or the active control, and followed up for 24 month.

Interventions

OTHERHammocks with LLIN

Locally-made hammocks covered with long lasting insecticidal nel (LLIN)

OTHERStandard vector control measures

Insectice-treated net

Sponsors

National Institute of Malariology, Parasitology and Entomology, Vietnam
CollaboratorOTHER_GOV
London School of Hygiene and Tropical Medicine
CollaboratorOTHER
Institute of Tropical Medicine, Belgium
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* All residents in the 20 concerned study clusters and willing to give informed consent to participate

Exclusion criteria

* People not willing to give informed consent to participate

Design outcomes

Primary

MeasureTime frame
Reduction of malaria prevalence and incidence24 months

Secondary

MeasureTime frame
Reduction of malaria sero-prevalence24 months

Countries

Vietnam

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 2, 2026