Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment

A Randomized Clinical Trial on the Use of Early Intermittent Non-Invasive Ventilation in Patients Suffering From Acute Lung Injury After Allogeneic Transplantation

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00852605

Enrollment

Registered

2009-02-27

Start date

2001-12-31

Completion date

Unknown

Last updated

2009-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Lung Injury

Keywords

Acute Lung Injury after allogeneic transplantation

Brief summary

Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation. The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.

Interventions

OTHERIntermittent Non-Invasive Ventilation

Study design

Allocation

RANDOMIZED

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

patients undergoing allogeneic transplantation presenting with at least two of the following criteria * Respiratory rate \>25 / min * Oxygenation Index \<300 * Continuous oxygen-saturation \<92% whilst breathing room air

Exclusion criteria

* Indication for Emergency intubation * Hemodynamic instability * Left ventricular failure * GCS \<8 * No consent

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026