Chronic Sinusitis
Conditions
Keywords
Endoscopic sinus surgery
Brief summary
Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.
Interventions
DRUG1% lidocaine with 1:100,000 adrenaline
high dose
DRUG1% lidocaine with 1:200,000 adrenaline
1% lidocaine with 1:200,000 adrenaline
Sponsors
University of Toronto
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* recurrent acute sinusitis, chronic sinusitis, or nasal polyposis
Exclusion criteria
* bleeding disorders, under age of 18, history of cardiac disease or on antihypertensive medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of Intraoperative bleeding | during surgery |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamic fluctuation | during surgery |
Countries
Canada
Contacts
Primary ContactAli Moshaver, MD
Outcome results
None listed