Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair

Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients Undergoing Abdominal Aneurysm Repair.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00851149

Acronym

KEEP-HB

Enrollment

Registered

2009-02-25

Start date

2009-11-30

Completion date

2010-05-31

Last updated

2010-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Diseases, Osteoarthritis, Hip

Keywords

aorta, disease, abdominal, surgery, Osteoarthritis, Hip, replacement, blood, autolog, transfusion, cytokines

Brief summary

The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?

Detailed description

Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery. Primary outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. Secondary outcome: Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.

Interventions

DEVICESangvia blood sampling system

Blood collected from abdominal aortic repair patients are compared against blood collected from total hip replacement patients

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA 1-4

Exclusion criteria

* Patient using corticosteroids, NSAIDs or Cox-II inhibitors * Patients under 18 years * Patients who are included in pharmaceutical studies * Opioids-, benzodiazepines-, antiepileptic drugs-, alcohol- and α2-agonists abuse * Pregnant and breastfeeding women * Patients with known hypersensitivity for opioids, propofol or volatile anesthetics * Patients with serious arrhythmias (atrial fibrillation/flutter is acceptable) * Uncontrolled hypertension, serious psychiatric disease * Patients with unstable angina pectoris or myocardial infarction the last month before inclusion * Acute abdominal aortic surgery (acute dissection or rupture) * Planned laparoscopic abdominal aortic aneurysm surgery * Transfusion of blood products last month before surgery * Glucocorticoid users

Design outcomes

Primary

Measure	Time frame
Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.	30 days

Secondary

Measure	Time frame
Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.	30 days

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026