Bladder Cancer
Conditions
Keywords
Bladder cancer, Genetic susceptibility, Increased Risk
Brief summary
This clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer. Researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.
Detailed description
Researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.
Interventions
BEHAVIORALInterviews
Data collected by personal interview for Epidemiology and Nutrition Questionnaires, with personal and follow-up telephone interviews.
Sponsors
M.D. Anderson Cancer Center
National Cancer Institute (NCI)
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Subject has a histologically confirmed diagnosis of superficial or muscle-invasive bladder cancer * Subject is a Texas resident. * Subject can understand English or a qualified translator is available for the interview. * Subjects of any age, gender, or ethnicity are eligible to participate in the study. * Subject consents to participate in the study.
Exclusion criteria
* Subject has had prior treatment with systemic chemotherapy or radiotherapy in the past 6 months. * Subject has been diagnosed with superficial or muscle-invasive bladder cancer more than twelve months ago.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of mutagen sensitivity susceptibility assays that quantifies the number of lymphocytic chromatid breaks induced by in vitro exposure to bleomycin and the number of breaks induced by in vitro exposure to a tobacco carcinogen | After last subject has completed the study, up to 5 years | Mutagen sensitivity as measured by quantifying the number of lymphocytic chromatid breaks and comet tail moments induced by in vitro exposure to bleomycin (a radiomimetic agent) and benzo\[a\]pyrene diol epoxide (BPDE, a tobacco carcinogen) in bladder cancer cases in comparison to data for controls |
Secondary
| Measure | Time frame |
|---|---|
| Frequencies of polymorphisms in those genes that regulate the metabolism of carcinogens in tobacco smoke | After the last subject completes the study, up to 5 years |
| Associations between the cytogenetic, molecular components and epidemiologic covariates (age, sex, ethnicity, cigarette smoking status, alcohol use, dietary intake, and family history of cancer) in risk of bladder cancer | After the last subject has completed the study, up to 5 years per individual participation |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJian Gu, MD
M.D. Anderson Cancer Center
Outcome results
None listed