Cognition
Conditions
Keywords
H1-antagonist, Event Related Potentials, Memory, Information processing, The effects of an H1 antagonist (dexchlorpheniramine) on human cognition
Brief summary
The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.
Detailed description
The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.
Interventions
DRUGdexchlorpheniramine, lorazepam
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy as determined by a physician
Exclusion criteria
* present or history of any neurological of psychiatric disease * present or history of any substance abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P300 latency and LRP onset latency | 1.5 hours after treatment |
Secondary
| Measure | Time frame |
|---|---|
| Words recalled | 1.5 hours after treatment |
Countries
Netherlands
Outcome results
None listed