Postprandial Endothelial Dysfunction After a High-Fat Meal in HIV-infected Men

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00846599

Acronym

PERTH

Enrollment

Registered

2009-02-18

Start date

2008-01-31

Completion date

2010-01-31

Last updated

2017-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Risk, HIV Infection, HIV Infections

Keywords

brachial artery ultrasound, brachial artery reactivity, HIV, human immunodeficiency virus, cardiovascular risk, omega three, saturated fat, sustiva, atripla, kaletra, treatment naive

Brief summary

The purpose of this study is to examine the postprandial (anytime after a meal) effect of different dietary fats on endothelial function in HIV-infected and HIV-uninfected men.

Detailed description

This study requires two visits. Once determined eligible by the study criteria, during the first visit the participant will be randomly placed to receive one of two high-fat meals. The participant will receive the other study meal during the second visit. At each visit, brachial artery ultrasounds will be performed before and 3 hours after the meal is eaten. The sample size is 50 subjects. This study will be conducted at the Clinical Research Center at Tufts Medical Center.

Interventions

OTHEROmega-3 study meal

Participant will eat a study meal high in omega-3 fatty acids.

OTHERSaturated fat study meal

Participant will eat a study meal high in saturated fat.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* HIV-positive white male aged \>18 years * Under one of the following treatment categories: * Treatment naive or have never taken any HIV medications * Taking Kaletra * Taking Sustiva * Taking Atripla

Exclusion criteria

* Smoker * Pre-existing diagnosis or treatment for the following: * Lipid disorder * Cardiovascular disease * High blood pressure * Diabetes * Acute opportunistic infection or malignancy within last 3 months or current therapy for either * Active IV drug use

Design outcomes

Primary

Measure	Time frame
To measure flow-mediated dilation before and after eating the two study meals.	Study visit 1 and 2

Secondary

Measure	Time frame
To compare the effect of different dietary fats on endothelial function.	Study visit 1 and 2

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026