Implantation Rate
Conditions
Keywords
local injury, implantation rate, endometrial receptivity, IVF
Brief summary
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
Detailed description
Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.
Interventions
PROCEDURElocal injury
In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed
Sponsors
Yazd Research & Clinical Center for Infertility
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Age \< 35 * First IVF cycle * Long protocol should be used for stimulation
Exclusion criteria
* Day 3 FSH \> 10
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| implantation rate | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate | 4 weeks |
Countries
Iran
Outcome results
None listed