Vitamin B12 Deficiency
Conditions
Keywords
vitamin B12 deficiency, cyanocobalamin deficiency, proton pump inhibitors, omeprazole
Brief summary
This study was designed to determine whether elderly residents of long term care facilitated who had been taking proton pump inhibitors (PPI) for more than 12 months were more likely to have vitamin B12 deficiency than residents not taking PPI, and whether cyanocobalamin nasal spray improved these subjects' vitamin B12 status.
Detailed description
Subjects had serum creatinine \<1.8 mg/dL, no diagnosis of severe megaloblastic or pernicious anemia, and had not been taking vitamin B12 supplements. At baseline, serum vitamin B12 and methylmalonic acid (MMA) concentrations of 34 subjects from the PPI group were compared with those of the non-PPI group. The PPI group (n=13) was treated with cyanocobalamin nasal spray for eight weeks, and post-treatment vitamin B12 and MMA concentrations were compared with baseline concentrations.
Interventions
OTHERblood collection
blood collection
DRUGtreatment (cyanocobalamin nasal spray)
cyanocobalamin nasal spray -- 500 mcg q week for eight weeks
Sponsors
University of Delaware
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* age 60-89 years * PPI use for \>12 months (PPI group) * no PPI use for 30 days prior to arm 1 * long term care resident
Exclusion criteria
* pernicious anemia * severe megaloblastic anemia * free-living * serum creatinine \> 1.8 mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum vitamin B12 | baseline and after 8 weeks of treatment |
| serum methylmalonic acid (MMA) | at baseline and after eight weeks of treatment |
Countries
United States
Outcome results
None listed