Cardiac Arrest, Hypothermia
Conditions
Keywords
Sudden Cardiac Arrest, Hypothermia, Outcome, neurological, Coolgard, ArcticSun
Brief summary
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA. Postresuscitative mild induced hypothermia (MIH) lowers mortality and reduces neurologic damage after cardiac arrest. The investigators evaluated the efficacy and side effects of therapeutic hypothermia in an unselected group of patients after SCA.
Detailed description
Consecutive patients with restoration of spontaneous circulation (ROSC) after resuscitation due to out-of-hospital SCA, admitted to our intensive care unit, underwent MIH. Hypothermia was induced by infusion of cold saline and whole-body-cooling methods (electronic randomization: invasive Coolgard or non-invasive ArcticSun). The core body temperature was operated at 32 to 34 °C over a period of 24 hours followed by active rewarming. Neurological status was evaluated at hospital discharge and 6 months after discharge using the Pittsburgh Cerebral Performance Category (CPC). Blood samples of neuron-specific enolase (NSE) were collected during 72 hours.
Interventions
Sponsors
University of Leipzig
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* ROSC after SCA due to VF/VT or PEA/Asystolia * GCS 3
Exclusion criteria
* Non-cardiac SCA * Pregnancy * Unstable Circulation instead of High-dose Inotropics * Life-expectancy reducing concomitant illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to reach the target temperature | Twenty-four hours |
| NSE as a parameter for cerebral damage | Seventy-two hours |
Secondary
| Measure | Time frame |
|---|---|
| Neurologic outcome | Six months |
| Survival | Six months |
| Periprocedural complications | Seventy-two hours |
Countries
Germany
Outcome results
None listed