Liver Transplantation
Conditions
Keywords
Liver, transplant, albumin, outcome, Liver transplant recipients canadian transplant status 1 or 2
Brief summary
The purpose of the study is to examine if outcome after liver transplantation is improved by using albumin infusion post-transplantation.
Interventions
Patients in this arm will receive albumin infusions 3 times a day for the first 7 days post-operative
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years or older * Canadian Transplant status 1 or 2 * Patients at the Royal Victoria Hospital, Montreal, Canada
Exclusion criteria
* Emergency liver transplant (canadian transplant status 3 or 4) * patients who have received more than 300cc of albumin within 48 hours prior to transplant * patients who underwent previous solid organ transplant * multi-organs transplant recipients * patients who had previous adverse reaction to human albumin solution * patients who have religious restriction to receiving human blood products. * patients or surrogate unable to give consent to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post Transplant Liver Function Test (PTLFT) | Post-operative Day1 through 7 and Day 15,30, 45 |
Secondary
| Measure | Time frame |
|---|---|
| Calculated creatinine clearance | Post-operative day 1, 7, 15, 30, 45 |
| Length of hospital stay | post-operative |
| ICU length of stay | post-operative |
| duration of mechanical ventilation | post-operative |
| duration of renal replacement therapy | postoperative |
| Functional 6 minutes walking test | Post-operative |
| reintubation rate | post-operative |
| Post-operative infection rate | Post-operative |
| Need to re-operation unrelated to technical complication | post-operative |
| Functional hand grip Jamar Dynamometer hand grip test | Post-op day 7, 15, 30 |
| ICU readmission rate | post-operative |
Countries
Canada
Contacts
Primary ContactMathieu Rousseau, MD
Backup ContactMazen Hassanain, MD
Outcome results
None listed