Obesity
Conditions
Keywords
Obesity, Glucose metabolism disorders, Appetite regulation, Sleep, Adolescent, Randomized controlled trials
Brief summary
This study aims to investigate 1. whether sleep extension results in improvements of endocrine and metabolic markers of obesity and diabetes in obese teenagers, 2. the relationship between habitual sleep quality and duration and markers of obesity and diabetes in lean and obese teenagers.
Detailed description
Inclusion of 13 obese teens. Duration : 1 week of screening period + 1 week of intervention: habitual/extended sleep length + 1 week of intervention: extended/habitual sleep length. A wash out period of at least 3 months will be required between the two interventions. Inclusion of 13 non obese healthy teen controls for measuring reference sleep duration and physiology level. Duration for these group: 1 week of screening period + 1 week of habitual sleep length
Interventions
BEHAVIORALhabitual sleep length period + extended sleep length period
On obese group, realisation of an habitual sleep length period followed by an extended sleep length period
BEHAVIORALextended sleep length period + habitual sleep length period
On obese group, realisation of an extended sleep length period followed by an habitual sleep length period
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female over 15 and under 18 year-old. * Teenager with normal weight or stage 2 obesity, according to international standards (WHO) * Post-pubescent teenagers (menstruation for girls and stage 4-5 of Tanner scale for boys) * Teens with an social security * Girl with negative urine pregnancy test
Exclusion criteria
* Active smoker (interview) * Refuse consent (parents or teen) * Addiction such as coffee, drug…(interview) * Medicinal treatment that may influence sleep and measured variables (interview) * Obesity diagnosis : less than 1 year (interview) * Concomitant diseases : renal or hepatic failure, iron deficit, diabetes, endocrinal pathology, hypertension * Anxiety (Spielberg\>56), , depression (CDI\>19). * Mild or sever insomnia (ISI\>15), poor sleep quality (PSQI \>10), excessive sleepiness (Epworth\>10, sleep) length\>9 hour), extreme circadian typology (Horne et Ostberg from 70 to 86 or 16 to 30) * Blood sample taken within the last two months before inclusion * Mild or severe sleep apnoea or excessive leg movements according to EEG analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The influence of sleep extension on leptin level for the obese teens group. | at the end of each sleep experimental period |
Secondary
| Measure | Time frame |
|---|---|
| Difference between the two groups (obese vs non-obese) regarding sleep length and delta waves activity. | during each sleep experimental period (habitual or extended) |
| Study the correlation between delta waves activity and habitual sleep length | During each sleep experimental period |
| Study the correlation between delta waves activity and psychological, behavioural, anthropometric and physiological markers of obesity and its co morbidities | During each sleep experimental period |
Countries
France
Outcome results
None listed