PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial)

Permanent Atrial Fibrillation in Heart Failure Trial

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00839566

Acronym

PAF-HEFT

Enrollment

Registered

2009-02-09

Start date

2008-11-30

Completion date

2012-07-31

Last updated

2025-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Heart Failure

Keywords

Atrial Fibrillation, Heart Failure

Brief summary

Examination of CRT efficacy in patients with progressive heart failure and atrial fibrillation at the same time

Interventions

PROCEDUREAblation

AV-node ablation

OTHERRate Control

Rate control by drug

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* LVEF \<35% * QRS time ≥150ms LBB * NYHA classification ≥ NYHA III * permanent (\> 6 months) Atrial Fibrillation * sinus rhythm (control group) * Condition after Implantation of a Medtronic CRT device * written informed consent

Exclusion criteria

* exchange of the current CRT device * mitral incompetence (2. degree) * no compliance * participation in another study * pregnancy * patients with AV node * patients after heart transplant or those who are on the transplant list

Design outcomes

Primary

Measure	Time frame
End systolic left ventricular diameter	12 months

Secondary

Measure	Time frame
NYHA-Class, Echo-parameters, ECG-parameters, VO2 max,6 minutes hallwalk-test	12 months

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026