CABG-Induced Oxidative Stress
Conditions
Keywords
CABG, on pump, Grape seed extract, Vit C, Oxidative stress
Brief summary
Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
Detailed description
This study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery. There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group). 1. Control 2. GSE (100 mg/6h - PO, 24h before surgery) 3. Vit C (25 mg/kg in pump circulation during surgery)
Interventions
DRUGGSE
grape seed extract (100 mg/6h), PO
DRUGVit C (Ascorbic Acid)
Vit C 25 mg/ kg
Sponsors
Tabriz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Candidates for elective CABG surgery with pump for first time * 3VD
Exclusion criteria
* High risk patients * Those who need another heart surgery beside CABG * Urgent patients * Diabetics * Ischemic time more than 120 min
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF | Before and after CABG |
Secondary
| Measure | Time frame |
|---|---|
| Total Antioxidant Capacity (TAC) | Before ischemia, after ischemia, after reperfusion |
| MDA | Before, middle and after CABG |
| GTX | Before ischemia, after ischemia, after reperfusion |
| SOD | Before ischemia, after ischemia, after reperfusion |
Countries
Iran
Outcome results
None listed