Functional Imaging in HNC Undergoing Chemoradiation

Investigation of the Role of Functional Imaging in Characterising Radiotherapy Target Volumes and Assessing Disease Response in Patients Undergoing Chemoradiation for Head and Neck Cancer (HNC)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00837980

Enrollment

Registered

2009-02-06

Start date

2009-02-28

Completion date

2010-11-30

Last updated

2009-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Cancer

Keywords

head and neck cancer, DW MRI, PET, DCE MRI, functional imaging, IMRT

Brief summary

The purpose of the study is to generate a library of functional imaging and anatomical imaging for patients with head and neck cancers for evaluation of new radiotherapy strategies and planning techniques including IMRT. Secondary aims would be to observe the changes in the cancers as the treatment progresses as well as to define the biologically most active part of the tumor (biological target volume) which could be given more intensive treatment. Tumor volumes seen on different imaging modalities will be compared with a hope of finding an optimal imaging methodology for accurate visualization of the head and neck cancers

Detailed description

Adult patients who have a head and neck cancer and are planned to receive chemotherapy and radiotherapy will be invited to participate in the study. Patients who are not in very good health, have diabetes or kidney failure will not be considered for the study. Also patients who can not undergo MRI scan or are allergic to contrast injection given prior to the scan or have had any other form of cancer (except skin cancer) will also be excluded from the study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients with histologically proven head and neck cancer, planed for chemotherapy and radiotherapy * age more than 18 years * patient willing to participate and has signed a consent form * patients in good physical status (WHO performance status 0-2)

Exclusion criteria

* patients in poor health (WHO performance status \>2) * patients with any other cancer apart from skin cancer * patients with contraindications to MRI scan and IV contrast * diabetic patients * patients with renal failure

Design outcomes

Primary

Measure	Time frame
the number of patients completing the study protocol and adding to the library of images to be used for evaluation of new radiotherapy strategies and planning techniques including IMRT	—

Secondary

Measure	Time frame
the ability to define a biological target volume in all the patients	—
to compare the volumes defined by the conventional imaging to the functional imaging	—
to measure changes in the volume of the disease with diff	—

Countries

United Kingdom

Outcome results