Cognitive Impairment, Heart Failure
Conditions
Keywords
cognition, decompensation, heart failure, recompensation
Brief summary
The aim of the present study is threefold: investigating 1) specific cognitive impairments in patients with congestive heart failure, 2) whether cognitive impairments in patients with decompensated heart failure improve after medical recompensation and 3) whether cognitive functioning is related to the long-term prognosis (mortality, rehospitalisation) of those patients.
Detailed description
The daily routine in clinical settings often shows cognitive impairments in patients with congestive heart failure. Recent studies reported declines in cognitive functioning such as executive functions, episodic memory, perceptual speed and attention. However, less is known regarding the differential impairments of cognitive functioning in patients with decompensated heart failure. Study objectives: 1. Identifying specific cognitive impairments in patients with congestive heart failure compared to healthy controls 2. Evaluating the influence of acute decompensation in congestive heart failure on cognitive functioning 3. Investigating the effects of medical treatment on cognitive functioning in patients with decompensated heart failure 4. Exploring long-term effects of cognitive and physiological status on hospitalisation and/or mortality Study design: Cognitive functions of patients with decompensated heart (NYHA III-IV) failure are compared to age and gender matched patients with congestive heart failure (NYHA III-IV) without symptoms of cardiac decompensation and with healthy controls. Decompensated patients are tested before and after medical recompensation. For matched patients and controls, the pretest-posttest timing is based on the recompensation time of the respective patient with decompensated heart failure. The neuropsychological test battery includes measures of episodic memory, working memory, short-term memory, executive functions, perceptual speed and intelligence. In addition, the study applied standardized questionnaires of self assessed quality of life and depression. Relevant physiological data, such as left ventricular systolic function and N-terminal pro brain natriuretic peptide (NT-pro-BNP), are recorded.
Interventions
DRUGdiuretics, inotropica
Sponsors
Universität des Saarlandes
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Criteria of decompensated heart failure patients Inclusion Criteria: * decompensated heart failure patients * NYHA III-IV * ejection fraction \< 35%
Exclusion criteria
* psychosis * dementia * major depression * reanimation (\<3month) * patients with assist device system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function in decompensated heart failure patients measured by a cognitive test battery | within 48h of hospitalisation |
| cognitive function before and after medical recompensation measured by a cognitive test battery | individual time to recompensate |
| differences in cognitive performance between decompensated heart failure patients, patients with chronic heart failure and healthy controls | 14 months (+/-2 month) |
Secondary
| Measure | Time frame |
|---|---|
| all cause mortality | 12 month |
| long-term development of cognitive functioning in patients with heart failure after acute decompensation | 3, 6, 12 and 18 months after acute decompensation |
Countries
Germany
Outcome results
None listed