Stromal Gene Expression During Pulmonary Sarcoidosis

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00837668

Enrollment

110

Registered

2009-02-05

Start date

2005-04-30

Completion date

2012-02-29

Last updated

2017-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcoidosis

Keywords

sarcoidosis, stromal gene expression, pulmonary sarcoidosis, bronchoscopy

Brief summary

to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis. By so doing, we hope to identify unique genetic mechanisms which will aid in the diagnosis of sarcoidosis and will help us understand the pathogenesis of this poorly understood disease.

Detailed description

to collect small sample of lung tissue recovered from a clinical procedure such as bronchoscopy, or a mediastinoscopy (a procedure in which a lighted instrument (mediastinoscope) is inserted through a neck incision to visually examine the structures in the top of the chest cavity and to take a sample (biopsy) of tissue.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* diagnosis of sarcoidosis

Exclusion criteria

* inability to provide consent

Design outcomes

Primary

Measure	Time frame
To Identify Gene Expression Patterns That Specifically Correlate With Active Pulmonary Sarcoidosis.	end of study

Secondary

Measure	Time frame
To Determine if Gene Expression Patterns Correlate With The Severity of Illness Of Sarcoidosis Patients	end of study

Countries

United States

Outcome results