Acute Kidney Injury, Septic Shock, Severe Sepsis
Conditions
Brief summary
Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy. But there is no consensus for proper time of CRRT may improve the prognosis. The study is a prospective randomized one center trial comparing two treatments in patients suffering from septic shock complicated with acute renal failure admitted to ICU, treated either early by CRRT (35 ml/kg/h) or by conventional RRT.
Interventions
PROCEDUREcrrt
early CRRT (35 ml/kg/h)& acute kidney injury or failure or nearly anuria more than 2hr or late conventional dialysis indication
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Septic shock (Bone criteria) for less than 14D * RIFLE criteria : Injury or Failure or nearly anuria more than 2hr * Age over 18 years * Written informed consent by next of kin.
Exclusion criteria
* Cirrhosis child class C * CRF or ESRD * Too high APACHE II & SOFA score at admission * Age over 80 years * Life expectancy less than 3 months (metastatic cancer - hepatoma, lung ca.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death from all causes at 28 days after randomisation | 28 day |
Secondary
| Measure | Time frame |
|---|---|
| Death within the in the intensive care unit. Death within 90 days of randomisation. Death prior to hospital discharge. Length of ICU stay. The need for and duration of other organ support | 90 day |
Countries
South Korea
Contacts
Primary Contactsangbum hong, md
Outcome results
None listed