Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact

Autonomic Nervous System Alteration Induce by Sepsis:Assessment and Prognosis Impact

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00835913

Acronym

SNA&Sepsis

Enrollment

Registered

2009-02-04

Start date

2008-10-31

Completion date

2011-09-30

Last updated

2015-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock, Severe Sepsis

Keywords

Autonomic nervous system, Sepsis shock, severe sepsis, sinusal change, Myocardiac fixing, NTproBNP, Patient in intensive care unit with sepsis shock or severe, Sepsis

Brief summary

Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.

Detailed description

Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG. The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as Bone Criteria * hemodynamically stable situation * sinusal rhythm * Patient for social security

Exclusion criteria

* Minors * Patient under guardianship or trusteeship * pregnant or lactating women * diabetic * cardiomyopathy known and/or treated or detect in admission * electro-systolic process permanent or transitory * neurological history or degenerative pathology * chronic respiratory insufficiency * Chronic renal insufficiency

Design outcomes

Primary

Measure	Time frame
Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission	48 hours post admission

Secondary

Measure	Time frame
plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation	30 days

Countries

France

Outcome results