Atherosclerosis, Intermittent Claudication
Conditions
Keywords
Magnetic resonance, whole body, angiography, hybrid protocol, MRI
Brief summary
To compare to different approaches in whole-body magnetic resonance angiography of patients suffering peripheral arterial disease. Our hypothesis is that use of a new protocol improves the diagnostic quality of the WB-MRA procedure.
Detailed description
Patients suffering peripheral arterial disease must undergo imaging procedures before endovascular or surgical procedures. WB-MRA is an imaging procedure that can visualise the arterial system. WB-MRA can be performed in different manners. On option is to start the scan in the head region and continue down the body to the feet (standard protocol). Another option is to use a hybrid protocol that first examines the head and lower leg followed by examination of the pelvic and upper leg region. A comparison between the standard and hybrid protocols has not been performed in a 3T high magnetic field system, therefore we will perform such a study.
Interventions
PROCEDUREWhole body magnetic resonance angiography (WB-MRA)
WB-MRA will be performed once in each patient.
Sponsors
Rigshospitalet, Denmark
Copenhagen University Hospital at Herlev
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Symptomatic lower extremity ischemia (claudication, ischemic wounds) * Referred to digital subtraction angiography (DSA)
Exclusion criteria
* Renal insufficiency (GFR \< 30 ml/min) * Contra-indications for MRI-examination (claustrophobia, metal-implants, pacemaker) * Dementia * Pregnancy/lactation * Allergy to gadolinium based MRI contrast agents * Acute disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic quality of WB-MRA | — |
Secondary
| Measure | Time frame |
|---|---|
| Signal to noise ratio | — |
| Contrast to noise ratio | — |
Countries
Denmark
Outcome results
None listed