Influenza
Conditions
Keywords
Non pharmaceutical measures
Brief summary
With this study the investigators will try to assess the tolerability and measurability of the efficacy of non pharmaceutical measures to prevent seasonal influenza in individual households. Households with an identified index case of influenza will be randomised into one of three intervention arms: 1. group, where the household will receive general information about transmission of influenza virus and means to prevent it (Controls); 2. group, which will receive surgical masks and be asked to wear them whenever they are in close contact with the index case or other persons of the household that became ill during the observation period; 3. group, which will be given and asked to wear surgical masks as well as to execute intensified hand hygiene. In addition to assessing the secondary attack rate as our primary outcome measure, the investigators will also try to evaluate compliance to those interventions by questionnaires.
Interventions
DEVICEMasks
Wearing of surgical masks
DEVICEMasks & hand hygiene
Wearing of surgical masks and intensified hand washing
OTHERControl
General information about virus transmission in households and basic means to prevent it
Sponsors
Robert Koch Institut
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* influenza like illness symptoms * positive rapid test for influenza * inclusion within 48h of symptom onset * inclusion of at least 3 members of a household (including index case)
Exclusion criteria
* severe illness * other cases of similar symptoms within 14 days before onset of symptoms in index patient * severe asthma or COPD * pregnancy of index
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary infection with influenza of the household members who are healthy at the start of the study | — |
Countries
Germany
Outcome results
None listed