Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00833157

Enrollment

Registered

2009-01-30

Start date

2005-02-28

Completion date

2009-03-31

Last updated

2009-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the Knee

Keywords

Knee Osteoarthritis, exercise, strength training, Glucosamine, Dietary supplement, Ibuprofen, NSAID

Brief summary

The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis. The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

Interventions

DRUGglucosamine sulphate

Subjects are administered glucosamine-sulphate tablets of 500 mg \* 3 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks.

DRUGibuprofen

Subjects are administered 600 mg \* 2 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks

DRUGplacebo

Subjects are administered placebo tablets, while they are performing a strength-training program (\*3 weekly) with both legs for 12 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Age 50 to 70 years * Bilateral tibiofemoral osteoarthritis of the knee on x-ray * American College of Rheumatology (ACR) clinical classification criteria

Exclusion criteria

* Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases * Excess alcohol use (\> 21 alcoholic drinks per week) * Severe overweight (BMI \> 35) * History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion

Design outcomes

Primary

Measure	Time frame
muscle strength and hypertrophy	We measure before and after 12-weeks strength training.
cartilage biomarkers	We measure before and after 12 weeks strength training

Secondary

Measure	Time frame
muscle regeneration and function	We measure before and after 12-weeks strength training.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026