Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

The Influence of Blocking Inflammatory Activity in Vivo on Skeletal Muscle Regeneration in Humans

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00832663

Enrollment

Registered

2009-01-30

Start date

2009-04-30

Completion date

2009-12-31

Last updated

2010-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Damage

Keywords

Muscle regeneration, Satellite cells, electrical stimulation, eccentric contractions, myogenic precursor cells

Brief summary

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration. The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Detailed description

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Interventions

DRUGNSAID

Effect of NSAID ingestion on muscle regeneration

DRUGplacebo

receive placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* male * healthy * does not exercise regularly

Exclusion criteria

* displays contraindications for taking NSAID * well-trained

Design outcomes

Primary

Measure	Time frame
Muscle regeneration	1 month

Secondary

Measure	Time frame
Muscle strength	1 month

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026