Asthma, Rhinitis
Conditions
Keywords
asthma, rhinitis, swimmers, mannitol
Brief summary
The Scottish National and District swimming teams will be screened for asthma and rhinitis using both mannitol challenge and sport-based exercise challenge.
Interventions
OTHERno intervention
this is a screening study, not an interventional study
Sponsors
Brian J Lipworth
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
11 Years to 23 Years
Healthy volunteers
No
Inclusion criteria
* member of the Scottish national and district swimming team * informed consent obtained
Exclusion criteria
* pregnant, lactating or planning to become pregnant * concomitant use of medicines (prescribed, over-the-counter or herbal) that may interfere with the trial. * any clinically significant medical condition, as deemed by the clinical investigators, which may endanger the health of the participant or jeopardise the protocol. * inability to comply with the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tidal Nitric Oxide | This test will be performed prior to entering the pool, and on exiting the pool |
Secondary
| Measure | Time frame |
|---|---|
| Mannitol Challenge | This test will be performed once on a district and once on a national squad training day |
| Sport-based Challenge | This test will be performed once on a district and once on a national squad training day |
| Nasal Nitric Oxide | This test will be performed prior to entering the pool, and on exiting the pool |
| Skin Prick Test | This test will be performed once on a district and once on a national squad training day |
| Mini Nasal Lavage | This test will be performed prior to entering the pool, and on exiting the pool |
Countries
United Kingdom
Participant flow
Recruitment details
The scottish national and district teams were assessed during training weekends.
Pre-assignment details
All members of the squad were offered the opportunity to take part.
Participants by arm
| Arm | Count |
|---|---|
| Scottish Swimming Team | 97 |
| Total | 97 |
Baseline characteristics
| Characteristic | Scottish Swimming Team |
|---|---|
| Age, Categorical <=18 years | 97 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 0 Participants |
| Age, Continuous | 15.2 years STANDARD_DEVIATION 0.25 |
| Region of Enrollment United Kingdom | 97 participants |
| Sex: Female, Male Female | 52 Participants |
| Sex: Female, Male Male | 45 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 |
Outcome results
Primary
Tidal Nitric Oxide
Time frame: This test will be performed prior to entering the pool, and on exiting the pool
Population: Data from all participants was analysed
| Arm | Measure | Value (GEOMETRIC_MEAN) |
|---|---|---|
| Scottish Swimming Team | Tidal Nitric Oxide | 18.7 ppb |
Secondary
Mannitol Challenge
Time frame: This test will be performed once on a district and once on a national squad training day
Secondary
Mini Nasal Lavage
Time frame: This test will be performed prior to entering the pool, and on exiting the pool
Secondary
Nasal Nitric Oxide
Time frame: This test will be performed prior to entering the pool, and on exiting the pool
Secondary
Skin Prick Test
Time frame: This test will be performed once on a district and once on a national squad training day
Secondary
Sport-based Challenge
Time frame: This test will be performed once on a district and once on a national squad training day