Cognition, Embolism, Fat
Conditions
Keywords
Mental Cognition Change, Fat Embolism, Bone Marrow Debris Emboli, Computer Assisted Total Knee Arthroplasty, Conventional Instrumented Total Knee Arthroplasty
Brief summary
A significant number of patients experience postoperative cognitive changes following total joint arthroplasty. Among other causes, the mental status change may be the result of fat and bone marrow debris embolization. We hypothesized that the use of computer assisted total knee arthroplasty, which does not utilize intramedullary alignment rods, would produce less fat and bone marrow debris embolization and, hence, fewer mental status changes.
Detailed description
Inclusion criteria * Primary, cemented knee arthroplasty * Unilateral or bilateral TKA Exclusion criteria * Patient is unable to speak English * Unable to read and write * Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.) * Patients with history of IV drug abuse * Previous history of dementia * Patients on mental status changing medications
Interventions
DEVICETotal Knee Arthroplasty Implant (Scorpio®)
Implantation of a Total Knee Arthroplasty using Conventional Intramedullary Instrumentation
Sponsors
Rothman Institute Orthopaedics
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Primary, cemented knee arthroplasty * Unilateral or bilateral TKA
Exclusion criteria
* Patient is unable to speak English * Unable to read and write * Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.) * Patients with history of IV drug abuse * Previous history of dementia * Patients on mental status changing medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Folstein Mini Mental State Examination (MMSE) | 6 Months Post-Operative |
Outcome results
None listed