Stroke, Subarachnoid Hemorrhage
Conditions
Keywords
SAH, sedation, anesthesia
Brief summary
Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .
Interventions
DRUGPropofol
Propofol(3-4 mg/kg/ora)administrated for 2 hours.
DRUGIsoflurane
Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration
Sponsors
Azienda Ospedaliera San Gerardo di Monza
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of aSAH * indication to DVE positioning * clinical indication to sedation and assisted ventilation * indication to ICP and CBF monitoring * age \> 18
Exclusion criteria
* documented cranial hypertension (ICP\>18) not controller by liquor drainage * age \< 18.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral Blood Flow | after 2 hours of drug administration |
Countries
Italy
Outcome results
None listed