Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease

Water-and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease, Evaluated by the Excretion of Aquaporin-2 and Epithelial Sodium Channels in the Urine

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00830726

Enrollment

150

Registered

2009-01-28

Start date

2009-02-28

Completion date

2012-02-29

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Stenosis, Healthy Volunteers, Heart Failure, Ischemic Heart Disease, Pulmonary Hypertension

Keywords

Aquaporin, Epithelial Sodium Channels, Heart Failure, Valvular heart disease, Ischemic heart disease

Brief summary

The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.

Detailed description

The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)

Interventions

DRUGPharmacologic and mechanical heart failure treatment

Optimised, standard, evidence based heart failure therapy including the use of biventricular pacing.

PROCEDUREAortic valve replacement

Standard aortic valve replacement as per standard criteria in the department of thoracic surgery.

PROCEDURERevascularisation in Acute Coronary Syndrome

Standard percutaneous or surgical revascularisation in ACS.

PROCEDURERevascularisation in chronic stable angina pectoris

Standard percutaneous or surgical revascularisation

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Symptomatic heart failure * Severe valvular aortic stenosis * Acute Coronary Syndrome * Medically refractory chronic angina pectoris or pulmonary hypertension with preserved left ventricular function

Exclusion criteria

* Pregnancy * Drug abuse * Malignant disease * Significant disease of other organs including endocrine diseases

Design outcomes

Primary

Measure	Time frame
Differences in excretion of Aquaporin-2 in urine	6 months

Secondary

Measure	Time frame
Differences in excretion of Epithelial Sodium Channels in urine	6 months

Countries

Denmark

Contacts

Primary ContactOle Nyvad, M.D.

ole.nyvad@slb.regionsyddanmark.dk+45 76362257

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026