Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma

Alcoholic Cirrhosis, Carcinoma, Hepatocellular, Postoperative Hepatic Failure, Viral Cirrhosis

Hepatic functional reserve, Hepatocellular carcinoma (HCC), Indocyanine Green retention rate at 15 minutes (ICG-R15'), Portal Pressure (PP), Hepatic Portal Venous Gradient (HPVG), Alcoholic and Viral Cirrhosis, Makuuchi criteria, Barcelona Clinic of Liver Cancer (BCLC), Hepatic resection

The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and non-alcoholic aetiologies. Alcoholic and viral cirrhosis present important differences in terms of cellular mechanisms responsible for the disease progression with a distinct and unique gene expression pattern that regulates the type of inflammatory response. These differences probably influence the hepatic functional reserve and the onset of portal hypertension at a comparable clinical and biological level of derangement and the investigators may expect significant differences in the recovery from hepatectomy. The investigators' hypothesis is that at a comparable ICGR-15 rate non-viral cirrhotic liver presents higher portal pressure values and the investigators also argue that alcoholic cirrhotic patients would tolerate a larger hepatic resection than would viral cirrhotic do.

None listed

Switzerland