Preventing Childhood Antibiotic-associated Diarrhea by Prebiotics

Prebiotics in the Prevention of Antibiotic-associated Diarrhea in Children

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00826137

Acronym

WGAAD

Enrollment

200

Registered

2009-01-21

Start date

2008-12-31

Completion date

2010-07-31

Last updated

2012-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic-Associated Diarrhea

Keywords

prebiotics, Antibiotic-associated diarrhea

Brief summary

Prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.

Detailed description

Group will get either the product or placebo blindly throughout antibiotic treatment with additional 14 days.

Interventions

DIETARY_SUPPLEMENTInulin and fructo-oligosaccharides.

Supplement during antibiotic treatment+14 days.

DIETARY_SUPPLEMENTPlacebo

Placebo is base powder of product with no oligosaccharides.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

6 Months to 14 Years

Healthy volunteers

Inclusion criteria

* Healthy children with acute infection.

Exclusion criteria

* Hypersensitivity to antibiotics, chronic illness.

Design outcomes

Primary

Measure	Time frame
Prevention of diarrhea.	During antibiotic treatment+14 days

Secondary

Measure	Time frame
Duration of diarrhea.	During antibiotic treatment+14 days

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026