Non-Insulin-Dependent Diabetes Mellitus
Conditions
Keywords
Diabetes, lipids, fiber
Brief summary
Effect of Dietary Fiber on glucose, lipid, and mineral metabolism in patients with non insulin dependent diabetes mellitus.
Detailed description
Two diets will be compared,a low fiber diet and a high fiber diet. These two diets will differ only in the content of total dietray fiber derived from natural food products. The diets will be identical in terms of total energy, percentage of total energy as proteins, fat and carbohydrates.
Interventions
OTHERHigh Fiber and Moderate Fiber Diets
Dietary
Sponsors
University of Texas Southwestern Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* NIDDM * age 35 to 80 years * stable oral hypoglycemic treatment for at least one month * fasting triglycerides \< 500 mg/dl
Exclusion criteria
* insulin dependent NIDDM * insulin dependent diabetes * hepatic disease * significant hepatic dysfunction * signifiacnt renal dysfunction * presence of significant hematological, neurological, cardiovascular or gastrointestinal disorder, unless stable for past 6 months, * serious intercurrent illness or anticipated major surgery * female pregnant or likely to become pregnant * chronic drug abuse, alcoholism or psychaitric disorder within the past 2 years * treated with beta adrenergic blockers * on lipid lowering drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glucose and lipid metabolism | Baseline and during the last 5 days of each 6 week dietary phase |
Secondary
| Measure | Time frame |
|---|---|
| calcium isotope absorption in the gastrointestinal tract, stool mineral content, 24 h urinary mineral concentration, and serum chemistry including mineral concentration. | Baseline and during the last 5 days of each 6 week dietary phase |
Outcome results
None listed