Acute Lung Injury, Sepsis
Conditions
Keywords
biological markers, sepsis, acute lung injury
Brief summary
There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St. Michael's Hospital, Toronto, we have initiated a pilot study looking for biological markers to detect severe sepsis and ARDS. We have found that human neutrophils peptides (a-defensins), certain coagulation variables and cytokine levels are very sensitive markers to differentiate severe sepsis, ARDS from cardiovascular diseases in ICU patients. These findings may provide valuable information for therapeutic guideline in clinical practice. The present study will focus on testing 'biological markers' to identify patients with sepsis and acute lung injury. We will examine the roles of three components of markers including inflammation, neutrophil activation and coagulation. We are hoping that this proposed translational research will help develop novel therapeutic strategy in sepsis and acute lung injury patients.
Interventions
None listed
Sponsors
Chimei Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Meet diagnostic criteria of ≧2 SIRS or acute lung injury. * Get agreement of patient's attending physician and inform consent form patient or family.
Exclusion criteria
* Use Antibiotics over 24 hrs（only SIRS group）. * Active bleeding. * Pregnancy. * Active Cancer (refer to malignancy which is recently diagnosed, under treatment, or relapsed) * VS or Subject or Family refuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The present study will focus on testing 'biological markers' to identify patients with sepsis and acute lung injury in early stage. | 72 hrs |
Countries
Taiwan
Outcome results
None listed