Dexamethasone for Postoperative Nausea and Vomiting

Optimizing Anesthesia Antiemetic Measures Versus Combination With Dexamethasone or Ondansetron in the Prevention of Postoperative Nausea and Vomiting.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00825071

Enrollment

180

Registered

2009-01-19

Start date

2007-11-30

Completion date

2008-03-31

Last updated

2016-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting

Keywords

Postoperative Nausea and Vomiting, Ondansetron, Dexamethasone

Brief summary

The investigators want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy.

Detailed description

More than half of the patients undergoing laparoscopic cholecystectomy will have postoperative nausea and vomiting (PONV). PONV is related to surgical, anesthetic and patient factors. We want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of PONV in patients undergoing laparoscopic cholecystectomy. Three groups to be studied : (Group O) will receive 4 mg ondansetron, (Group D) will receive 8 mg dexamethasone and (Group P) will receive normal saline .

Interventions

DRUGDexamethasone

8 mg, Intravenous

DRUGOndansetron

4 mg, intravenously

DRUGnormal saline

2 ml, intravenously

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* (ASA) grade I and II, aged (18-70 years) who are scheduled for elective laparoscopic cholecystectomy under general anesthesia at the department of Anesthesia and Intensive Care, University of Jordan, Amman, Jordan between November 2007 and March 2008

Exclusion criteria

* All patients who received antiemetics or cortisone within 48 hr before surgery or those who required opioids before and after surgeries * Pregnant, breast feeding ladies * Any patient with BMI (Body Mass Index) \> 34 kg/m² * Patient with gastrointestinal, hepatic, renal, mental or psychiatric illnesses or those with history of motion sickness were also excluded from the study protocol

Design outcomes

Primary

Measure	Time frame
incidence of nausea and vomiting in each of the three studied groups.	5 months

Secondary

Measure	Time frame
Assess the postoperative Visual Analog Score for pain assessment in each of the three studied groups	5 months

Countries

Jordan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026