Skip to content

Use Bronchoscopy to Predict Post-Extubation Stridor in Critical Ill Patients

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00824096
Enrollment
100
Registered
2009-01-16
Start date
2006-12-31
Completion date
2009-12-31
Last updated
2009-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Extubation Stridor

Keywords

endotracheal intubation, cuff-leak test, post-extubation stridor, bronchoscopy, corticosteroids, Cuff-leak volume less than 24%

Brief summary

Our study aims at the accuracy of bronchoscopy to predict PES. Evidence base medicine guidelines for extubation may be obtained through this study.

Interventions

PROCEDUREBronchoscopy

The patients in our ICU intubated for \> 24h and met weaning criteria, will be examined by bronchoscopy. Five ㏄ blood will be collected for checking CRP and cytokines before performing bronchoscopy. The proposed grading of post-extubation vocal cord finding were shown (Figure 1). The patients will be classified to two groups (Figure 2). The first group is these patients without swelling or swelling area ≦50% who will be extubated after bronchoscopic examination. These patients will be followed for 48 hours to monitor the incidence of PES. The second group is those patients who develop laryngeal edema with swelling area ≧50% or swelling in the whole vocal cord. Bosmin 2 ml local injection and Solu-medrol 40 mg I.V. Q6h for 1\ 4 days will be given. Bronchoscopy will be done if CLV ≧24% or after treatments for 3\ 4 days even with CLV \<24%. The above treatments will be applied again if stridor develops. Extubation will be performed if no presence of laryngeal edema.

Sponsors

Chimei Medical Center
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age equal or greater than 18 years old * Intubation over 24 hrs * Match weaning profile * Cuff leak volume less than 24% * VS and subject/family agree

Exclusion criteria

* Re-Intubation * History of upper air way obstruction * Severe CV disease (ex. AMI) * Active UGI Bleeding * Blood sugar persistent more than 250 mg/dl under medication control * Risk of IICP * Open T.B. * Bleeding tendency/ Platelet less than 40 thousands * Subject or family refuse

Design outcomes

Primary

MeasureTime frame
The accuracy of bronchoscopy to predict post-extubation stridor.48 hours

Countries

Taiwan

Contacts

Primary ContactKuo-Chen Cheng
n940721@mail.chimei.org.tw886-6-281 2811

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026