Infertility
Conditions
Keywords
GnRH antagonist, GnRH agonist, pregnancy rate, Ovarian stimulation
Brief summary
Literature suggests that GnRH antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. Up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique. This prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of ART. The investigators will randomize 160 patients undergoing ART for the first time . Group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with GnRH antagonist and then result of ART compare in two group .
Interventions
DRUGganirelix
These patients started ovarian stimulation with 150 - 225 IU Gonal F on the second day of menstrual cycle with an S.C. injection once a day. Initiation of 0.25 mg Ganirelix took place on the 6th of the stimulation (fixed protocol) when HMG (Menogon, ferring, pharmacenticals , Germany ).
DRUGsuprefact
GnRH agonist, standard protocol
Sponsors
Yazd Research & Clinical Center for Infertility
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* first cycle of ART * age \< 35 years * basal FSH \< 10 IU/L
Exclusion criteria
* previous IVF or ICSI, hyperprolactinemia, hyperthyroidism, hypothyroidism, uterine abnormality, severe endometriosis * only one ovary
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate | 2weeks |
Secondary
| Measure | Time frame |
|---|---|
| ovarian stimulation | 10days |
Countries
Iran
Contacts
Primary Contactrazieh firouzabadi, MD
Backup Contactshahnaz Ahmadi, MD
Outcome results
None listed