Metabolic Syndrome and Gen-polymorphs Influence on Weightloss Among Children in Treatment for Overweight

Indicators for the Metabolic Syndrome as Well as the Influence of Different Gen-polymorphs on Weightloss and the Maintenance of Lower Weight Among Children in Treatment for Overweight

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00823277

Enrollment

517

Registered

2009-01-15

Start date

2009-01-31

Completion date

2012-08-31

Last updated

2023-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Obesity, Hyperlipidemia, Hypertension, Insulin Sensitivity, NAFLD (Non-alcoholic Fatty Liver Disease)

Brief summary

Definition: the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity. The specific aims are to; * describe the degree of NAFLD among overweight and obese, Danish children. (hypothesis; the degree for pediatric NAFLD among Danish Children was equal that found in other Caucasian paediatric study populations). * investigate the effect of a multidisciplinary intervention treatment of 1 year on liver fat content. (hypothesis; the intervention could reduce the liver fat percentage and a reduction in BMI SDS would associate with a reduction in liver fat content) - Analyze changes in liver fat content in relation to changes in levels of fasting blood variables to see if any of them could be used as a clinical tool for monitoring hepatic steatosis in the clinic. (hypothesis; serum aminotransferases (separately and their ratio, respectively), serum insulin, and HOMA-IR could predict improvement in liver fat content \- Investigate the association between genetic variants and obesity.

Interventions

OTHERChronic care multidisciplinary intervention of childhood obesity

Overweight and obese Children, 5-20 Years old, followed by Paediatricians and other Health Personals (multidisciplinary team). Included at their first visit in the clinic (baseline)and follow-up after \ 1 Year.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 20 Years

Healthy volunteers

Yes

Inclusion criteria

* 5- 20 Years old. * Adipose. BMI \> 90 % percentile * New patient in the Children's Obesity Clinic, Paediatric Department, University Hospital Holbaek,Region Zealand, Denmark * Informed Consent

Exclusion criteria

* Drop-outs

Design outcomes

Primary

Measure	Time frame
weightloss	1 Year

Secondary

Measure	Time frame	Description
NAFLD (non-alcoholic Fatty Liver Disease).Gene-polymorphs	1 Year	Nafld measured by Magnet resonance spectroscopy. Sequencing of MC4R

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026