Glycemic Control, Type 2 Diabetes
Conditions
Keywords
Type 2 diabetes, Glycemic control, (postprandial) Hyperglycemia, Sucrose
Brief summary
Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes. The objective of the study was to assess glycemic control in type 2 diabetes patients and healthy lean and obese controls under strict dietary standardization but otherwise free living conditions, with and without the consumption of soft drinks.
Interventions
DIETARY_SUPPLEMENTSucrose consumption
Sucrose
DIETARY_SUPPLEMENTwater consumption
water
Sponsors
Suikerstichting Nederland (Baarn)
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Lean NGT Group * Normoglycemic (according to 2006 ADA guidelines) * BMI \< 27 kg/m2 Obese NGT Group * Normoglycemic * BMI 30- 35 kg/m2 Obese type 2 diabetes Group * BMI 30- 35 kg/m2 * Oral blood glucose lowering medication
Exclusion criteria
* Exogenous insulin use * Cardiac disease (any cardiac event in the last 5 years) * HbA1c \>10% * Microalbuminuria: albumin:creatinine ratio \>2,5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperglycemia | 24h |
Secondary
| Measure | Time frame |
|---|---|
| Hyperglycemia | Postprandially |
Countries
Netherlands
Outcome results
None listed