Acute Kidney Injury, Acute Kidney Insufficiency, Acute Renal Insufficiency, Ischemic Preconditioning
Conditions
Keywords
Acute Kidney Insufficiency, Acute Renal Insufficiency, Acute Kidney Injury, Cardiac Surgical Procedures, Ischemic Preconditioning
Brief summary
Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.
Interventions
PROCEDURERemote Ischemic Preconditioning
Three 5-minute intervals of leg ischemia induced by tourniquet inflation, prior to initiation of cardiopulmonary bypass.
Sponsors
MaineHealth
Robert Kramer, MD
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patient undergoing heart surgery on cardiopulmonary bypass.
Exclusion criteria
* Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection. * End-stage renal disease. * Inability to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl. | 48 hours after surgery. |
Secondary
| Measure | Time frame |
|---|---|
| Oliguria. | 12 hours after surgery. |
| Incidence of acute kidney injury as defined by post-operative elevation in NGAL. | 3 hours after cardiopulmonary bypass. |
Countries
United States
Outcome results
None listed