The DIEP Flap as a Model of Ischemia-Reperfusion: an Intervention Study

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00821158

Enrollment

Registered

2009-01-13

Start date

2009-02-28

Completion date

Unknown

Last updated

2009-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemia-Reperfusion

Brief summary

The investigators will examine whether administration of certain medications will decrease or prevent ischemia-reperfusion injury.

Interventions

DRUGAntioxidant

Antioxidant iv bolus

OTHERPlacebo

Placebo tablet and iv

DRUGAnti-inflammatory drug

Anti-inflammatory tablet

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoing breast reconstruction

Exclusion criteria

* Diabetes mellitus * Kidney or liver disease * Use of immunosuppressants

Design outcomes

Primary

Measure	Time frame
Antioxidant concentrations	0,5-24 hours

Countries

Netherlands

Contacts

Primary ContactMarieke van den Heuvel, M.D.

m.vandenheuvel@ah.unimaas.nl0031-43-3875496

Backup ContactR. van der Hulst, M.D., Phd

r.vander.hulst@mumc.nl0031-43-3877481

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026