A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS)

An Open-Label, Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug System (L-PPDS) in Subjects With Ocular Hypertension (OH) or Open-Angle Glaucoma (OAG)

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00821002

Enrollment

Registered

2009-01-12

Start date

2009-01-31

Completion date

2009-11-30

Last updated

2013-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ocular Hypertension, Open-Angle Glaucoma

Keywords

Glaucoma

Brief summary

The study objective is to compare IOP and safety outcomes based on plug placement (upper or lower puncta).

Interventions

DRUGLatanoprost

Comparison of punctal plug placement between upper and lower puncta

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Over 18 years * Diagnosed with bilateral Open-Angle Glaucoma or Ocular Hypertension

Exclusion criteria

* Uncontrolled medical conditions * Subjects who wear contact lenses * Subjects requiring chronic topical artificial tears, lubricants, and /or requiring any other chronic topical medications

Design outcomes

Primary

Measure	Time frame
Intraocular pressure change from baseline (mmHg)	6 weeks

Secondary

Measure	Time frame
Number of subjects with adverse events	6 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026