Biomarkers in Pulmonary Hypertension Associated to Interstitial Lung Disease

The Prevalence of Pulmonary Hypertension and the Significance of Different Biomarkers in Chronic Interstitial Lung Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00820729

Enrollment

212

Registered

2009-01-12

Start date

2009-03-31

Completion date

2011-03-31

Last updated

2012-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biomarkers, Interstitial Lung Disease, Pulmonary Hypertension

Keywords

interstitial lung disease, pulmonary hypertension, biomarkers, NT-pro-BNP, von Willebrand factor, D-dimer, Exhaled NO, Troponin-t

Brief summary

The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of patients with interstitial pulmonary disease. The aim of this study is to estimate the frequency of an increased blood pressure in the lungs among patient with interstitial pulmonary disease, and to evaluate the use of different biomarkers in diagnosis of the condition.

Detailed description

The presence of increased pulmonary blood pressure is established by echocardiography and confirmed by right heart catheterization. The ability of NT-proBNP, vWf, troponin-t, D-dimer and exhaled NO to predict the presence of increased pressure in the pulmonary circulation is evaluated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Interstitial pulmonary disease

Countries

Denmark

Outcome results